Promising new treatment for acute myeloid leukaemia Posted on June 10, 2016February 25, 2018 by Carly du Toit Patients with acute myeloid leukaemia (AML) can look forward to the development of new therapies following a discovery by cancer researchers at Walter and Eliza Hall Institute. While investigating ways to target particular types of AML, and hoping to increase the chance of a cure for the patient while limiting damage to healthy cells, the team discovered a new way to kill cells that are dangerously multiplying. A process known as apoptosis (programmed cell death) is a natural and necessary response to keep the proliferation of human cells in check. Apoptosis is interrupted in cancers, including AML, leading to unchecked cell growth. Dr. Gabriela Brumatti said traditional chemotherapies, which encourage apoptosis, have a high relapse rate. For example, within five years of completing treatment, half of AML patients suffer a relapse of their cancer, and of those who relapse, only 50 percent survive. Her team tried a ‘blue sky’ approach, inhibiting apoptosis of AML cells in order to unleash an alternative form of cell death called necroptosis. They found that the necroptosis cell death pathway was more effective at killing AML than apoptosis. In preclinical trials, they used a combination of drugs – birinapant, a new anti-cancer drug, and emricasan, a US Food and Drug Administration (FDA) approved inhibitor of apoptosis – to kill AML. “It has been speculated that inducing necroptosis might be an effective way to kill cancer cells,” said Professor Silke. “Our work now demonstrates clearly it is a clinically feasible and safe approach.” Dr. Brumatti suggested that since cancer cells often acquire resistance to traditional chemotherapy-induced apoptosis, this novel type of chemotherapy has the potential to be used to treat otherwise impossible to treat leukaemias. These findings have just been published in the research journal Science Translational Medicine. The Australian Cancer Research Foundation has supported WEHI by providing three grants, totalling AUD 5.5million towards cutting edge cancer research equipment and technology. The original news post was published on the WEHI website. Images of the research team courtesy of WEHI.
Basia and Gary’s Story Posted on February 15, 2016February 25, 2018 by Carly du Toit “I was pacing the lounge room floor feeding Grayce when I heard a car door slam out the front. Just for a second, I thought he’d come home, that he had been out for dinner with the boys, that the last six months had disappeared. It felt nice, for one second, like it used to be. I hope there are other fleeting moments like that. Because just for a second, I was in that other life and I remembered how it felt to be happy. I lost my husband, Gary, to oesophageal cancer 19 days after we were married. Our third child, Grayce, was born four weeks later. Though our time together was short we managed to fit a lot of life into those years. We also had lots of quiet moments, just enjoying spending time with each other. He was very hands-on around the house and with the children. There was nothing he loved more than to potter around on the weekends doing the jobs he had listed during the week, fixing things and finding better ways of doing things and then we would have our coffee mid-morning sitting in the backyard. We would email each other every day at work – just a few words here and there, or an interesting article. I miss all the little things that made our lives so much fun. The touch of his skin, a thousand gestures. Gary’s battle with cancer started on the 2nd of July and lasted for twelve and a half weeks. As the cancer ate away at Gary, I thought he looked more beautiful. His spirit, grace and dignity shone through more with each passing day. He was the perfect patient. He never complained and would try and help me help him as much as possible, even trying to lift and move his legs with his hands, and I would tell him off each time. That’s why we decided to call our daughter Grayce with a ‘y’ – grace for how much of it shone through him during this battle. The four letters of Gary’s name are carried on in the name of his daughter. That was his next goal, and what he told the doctors at his last oncology appointment. He wanted to meet his daughter. In the end I couldn’t ask it of him. I knew he could hear everything I was saying. I lay down on the bed next to him and put his right hand on top of my belly. I told him I loved him so. I said, ‘I don’t want to let you go but I have to. It’s time for you to go.’ He opened his eyes and deliberately blinked at me for the first time in hours. Then he took two more breaths and went. I still cannot bring myself to stretch out across the whole bed. It will mean finally admitting to myself that he won’t be riding his bike home and pushing it through the open door. That he won’t be bending down to hug the kids as they come running to greet him, squealing with delight. I know those things cannot happen but I still see them. I wish them. I live them in my head. They say memories are golden. Well maybe that’s true, but I never wanted memories, I only wanted you.” – ACRF Supporter, Basia We can’t bring Basia’s husband back to her but we can stand beside her while she continues to battle cancer through supporting research. To help her in her mission to protect others from having to go through what she went through click below. DONATE NOW
Ruth Robinson, Regular Giver of the Month Posted on November 17, 2015March 13, 2018 by Carly du Toit “My dear friend and colleague, Andrew “Sid” Sidoli had fair skin and freckles. While he loved surfing, he always tried to look after his skin by putting on sunscreen and a shirt or wetsuit but it still wasn’t enough in the end. He was on holidays with his sister, Rebecca, when she noticed an abnormality on his back and told him he needed to get it checked. The lesion turned out to be melanoma. But from the day of his diagnosis Andrew fought it with everything he had and remained optimistic. One day when I saw him in the corridor at work he told me ‘I’ve been given a 10% chance of survival, and while I have a 10% chance, I have hope.’ Sid was larger than life, he always had a cheeky smile on his face and everyone at work loved and respected him. He made time for everyone and was really supportive when my Mum passed away. He encouraged me, and I think most people in his life, to get our skin checked regularly. He later became bedridden when the melanoma spread to his lungs and brain. His doctor, the well-known, Charlie Teo did everything he could for him, but at just 40 years old my beautiful friend sadly lost his battle. Unfortunately, Sid was amongst many of my work colleagues who had been affected by various cancer types over the years. I believe the only way we will fight this dreaded disease is through research, which is why I choose to support the Australian Cancer Research Foundation. I used to donate whenever I had spare money, which was about twice a year, but not long after Sid passed I signed up to be a regular giver. I realised that if I donated on a monthly basis it would help researcher’s fast track discoveries and ultimately save more lives. I donate just over $1 a day each month so it barely affects my daily budget. I have seen how advancements in cancer research can really help people. My brother in law, Noel Hughes is now battling liver cancer and the oral chemotherapy tablets he takes are far less traumatic for him than those that were available years earlier. If you can afford just $1 a day, please consider supporting the ACRF, cancer could affect anyone of us and at any time.” – Ruth Robinson, Regular Giver of the Month Share your story
Making a Difference in Michael’s Name Posted on October 15, 2015March 13, 2018 by Carly du Toit “My family has been touched by cancer a few times, but the two that hurt the most were the loss of my mother and then my husband. My mother was recently retired when she told me she had found a lump in her breast. After lots of convincing, my sisters and I finally got her to visit the doctor. What she hadn’t told us was that she had first noticed the lump six months ago and by then it had grown extremely large. This was 20 years ago and there weren’t many options available to her at the time. After fighting through 15 months of gruelling treatment she sadly lost her battle with breast cancer. Years later, Michael, my wonderful husband and the father of our four sons was diagnosed with pancreatic cancer at 54 years old. We were really shocked as he had always enjoyed good health and was not showing any symptoms other than an itchy feeling under the skin. Our doctor however, did not suspect good news and the blood test proved it. Michael endured a lot to try and beat the cancer. He went through one and a half rounds of chemo and underwent a very high risk operation called a Whipple procedure. Thankfully he made it through but it was a long, hard road to recovery after the extensive surgery. Thanks to the expertise of the doctors and their teams things began to look more positive, but we were only able to spend an extra 22 months with Michael before he passed away at 56 years old. I donate in Michael’s name each month and hope that my little bit will make a difference so we can find a cure for all cancers. I chose to support the Australian Cancer Research Foundation because it’s a non-profit organisation that awards grants to the most ground-breaking research teams in Australia. I know my donations will help cancer researchers to continue fast-tracking discoveries for the future.” – Jannelle Scerri, Regular Giver of the Month Learn more about becoming a regular giver. Share your story
Remembering Rosemary Posted on September 21, 2015March 14, 2018 by Carly du Toit “In the UK in 1998, my twin sister, Rosemary discovered a lump on her breast and was diagnosed with breast cancer at only 38 years old. Rosemary and her husband were busy parents with four kids – two teenagers Rachel and Tommy, an 11 year old daughter, Jenny and a 9 year old son, Sam. Her illness was extremely hard on the whole family. We felt powerless as we watched her endure so much pain and distress at the thought of leaving her children. Rosemary fought courageously and was an inspiration to her community. Her friends and neighbours rallied to support the family during their time of need. The locals made renovations to their house to make her life easier and raised money to send her on a trip to visit me in Australia. This was one of the happiest months of my life, we shared precious time reconnecting and reminiscing about our childhood. It was heart-warming to know that so many people were offering a helping hand where they could. Wednesdays became known as ‘Rosemary Day’ in the area and each week, for three whole years, a group of ladies would take her out for the day. They would visit beautiful and interesting places and then have dinner together at their favourite restaurant. After five years of suffering Rosemary sadly lost her battle on her daughter’s 11th birthday. It is now a bittersweet day for the family and each year on the anniversary the four children meet in the church garden to celebrate their mother. The two girls also “Run for Rosemary” in Mother’s Day fundraising marathons. As her twin sister I feel her loss greatly, it’s very upsetting for me knowing that she did not get to see her children grow up or meet her grandchildren. I know that Rosemary would be so proud of her family and how much they have cared for each other. Over the years, cancer has continued to touch the lives of friends and others around me. A couple of years ago my husband and I realised the importance of cancer research first hand when he was diagnosed with melanoma and took part in a research trial. He has since developed kidney cancer and is being treated with targeted immune therapy which would not have been possible a few years ago. I often think back to the time when Rosemary developed cancer and appreciate all the progress that has been made since then. I support the ACRF with a monthly donation and have left a bequest in my will. I know my donations go towards helping the ACRF fund the necessary equipment that allows researchers to make many more life-saving discoveries. I hope that together we can spare many families the heartbreak of losing their loved ones in the future.” ACRF Regular Giver of the Month, Ann Smith Learn more about becoming a regular giver. Share your story
Beneath the surface of skin cancer patients Posted on September 16, 2015March 14, 2018 by Carly du Toit Here at the ACRF we are proud to equip Australia’s leading cancer researchers with the resources they need to end cancer. Recently, a team of researchers from the University of Queensland discovered a protein that helps to control an important process in cell adhesion that is disrupted when someone contracts a disease such as skin cancer. The researchers said that the Australian Cancer Research Foundation Cancer Biology Imaging Facility at UQ’s Institute for Molecular Bioscience (IMB) played a vital role in this research. It is currently one of the largest and most comprehensively equipped facilities in Australia for both the imaging and screening of chemical and biological libraries. The facility was founded in 2010 with a $2.5 million ACRF grant and is home to 23 high-performance microscopes and supporting image data analysis workstations. PhD student Rashmi Priya at IMB says that what the research has done is clarify the role of the protein myosin in tissue integrity. “The protein Myosin is found at cell connection points and we now know that it plays a crucial role in regulating how cells stick together to form tissues in the body,” she said. “Our research has shown that this is because myosin protects a switch that acts as a stabiliser. This switch must be very tightly controlled as it affects many processes within the body. Too much or too little of this switch, or having it in the wrong place, can lead to diseases such as skin cancer, says Priya.” Professor Alpha Yap, who led the research team, says “The cells in all the tissues of our body die and have to be replaced as regularly as every 24 hours in the intestinal system. For this to happen, adhesion between cells must be carefully broken down and rebuilt, and we now have a better understanding of what it is that’s controlling this whole process.” The original article was published on the Institute for Molecular Bioscience website, click here to read more.
Using your talent to raise funds for cancer research Posted on June 30, 2015February 25, 2018 by Carly du Toit Every one of us has a unique set of talents, and our mission at the ACRF is to support Australia’s top cancer researchers to do what they do best. It’s not easy to find the motivation to explore your strengths and creativity, but raising funds to help the experts find new treatments and cures for cancer might be just the inspiration you need! To help get your started, see what some of our supporters are doing. Music May Carrick is a police officer by day and a musician who records his albums by night, dedicating all proceeds to cancer research in honour of his father whom he lost to cancer two years ago. May first began writing music to help him cope. Check out his latest album here. Art Mikaela Designs is an amazingly talented sketch artist who recently showcased her work in honour of her late friend Casey. Her artwork was auctioned off to the highest bidder at an exhibition that she organised for cancer research. Jewellery Kirin Matthews is the founder of Jewellery for a Cause – a jewellery company with a passion for supporting charitable organisations and important causes. She donates 20% of each piece to charities such as the ACRF. View one of her latest creations here. If you’re still not sure what type of charity fundraising you want to do, you can visit our A-Z fundraising page for more fun ideas on how you can make the most of your own unique talents.
Alone, on foot, across the Simpson Desert, Ian Vickers is pushing himself to the limit for cancer research Posted on June 26, 2015March 14, 2018 by Carly du Toit In the next few days, Ian Vickers will be venturing out into the Australian outback to start his journey across the harsh terrain of the Simpson Desert. He will be travelling over 400 kms by foot – hauling his food and water supplies on a custom built cart. “I’ve been flat out the past week with last minute preparations, all is going well, feeling fit, strong and confident with a healthy dash of nervousness,” says Ian. He has chosen to dedicate this challenge to raise awareness and funds for cancer research. “There are many worthy charities whose name I could have chosen to support, however I lost both my parents to cancer far too early in their life, so it felt right to pick a charity that is dedicated to finding cures for this terrible disease. In fact, I believe that the success of my adventure will not only be measured by the completion of my walk but also in my ability to raise funds and awareness for cancer research.” Ian says he’s enjoyed every step of the journey so far. He has already invested an incredible amount of time and effort leading up to his quest, with the initial planning and preparations starting back in May of last year. “I literally walked the soles off a pair of old boots during one of my training sessions earlier in the year! I had a good friend of mine build a training rig consisting of scaffold poles and car tires that I could hook up to my new harness to drag up and down the beach.” And with all the hard miles put in he could not be more ready to embark on this remarkable adventure. “I’m relishing the new skills I’ve acquired along the way. I have a plan B, C or D for almost every eventuality should I run in to trouble along the way. But I have to credit all the support from friends, family and strangers alike, there’s no way I could have done this without them.” We are all very excited (not to mention a little bit anxious) for Ian, and wish the best of luck as he sets out to accomplish this extraordinary feat. To support Ian’s journey, visit his Everyday Hero Page here. Share your story
Giving regular charity donations through workplace giving! Posted on November 19, 2013February 25, 2018 by Carly du Toit One in two men and one in three women in Australia will be diagnosed with cancer by the age of 85. Each of us is keen to do our part to prevent both our loved ones and ourselves from facing this terrible disease, but often life gets in the way of us sitting down to make a donation. Workplace Giving is one way to get around this. It’s a simple way for working Australians to make a big difference to cancer research via regular charity donations that are deducted from your payroll, before tax. Employees can therefore enjoy an immediate tax benefit, while their regular charity donations work hard to make an important difference to our ability to fund cancer research. Continue reading “Giving regular charity donations through workplace giving!”
July is Regular Giving Month! Posted on June 27, 2013February 25, 2018 by Carly du Toit Regular Giving Month is an opportunity for us to celebrate our regular givers, both new and long-standing, for their incredible commitment to world-class cancer research in Australia. Through their regular charity donations, this amazing group of people have together raised more than $1.3 million! For this, and for their ongoing support, we will be forever grateful: they are a vital part of our work, ensuring we are able to fund the high-quality, world-class research grant applications we receive each and every year. Together, they are speeding up new treatments and cures for cancer. One of our newest regular givers, Stephen Holyoak, joined our Partner in the Cure program because his life has been changed forever by this terrible disease. “After losing my mum to cancer far too young, I felt it was time to try and help those who are suffering today and tomorrow.” “I have been unfortunate to also see very close friends lose family members to this horrible disease.” Continue reading “July is Regular Giving Month!”
