Discovery of four pancreatic cancer sub-types raises hope for future treatments. Posted on February 27, 2015February 25, 2018 by Carly du Toit ACRF funding has enabled a new discovery which will improve pancreatic cancer treatments of the near future. Sydney’s Garvan Institute of Medical Research, the University of Queensland’s Institute for Molecular Bioscience (IMB), and QIMR Berghofer Institute of Medical Research collaborated with researchers from the Wolfson Wohl Cancer Research Centre in Scotland, to analyse the complete genetic code of pancreatic tumours in 100 patients. The team identified and mapped out the extensive and damaging genetic changes – finding four key subgroups which differentiate pancreatic tumours by their gene arrangements: ‘stable’, ‘locally rearranged’, ‘scattered’ and ‘unstable’. Professor Sean Grimmond from IMB said, “Having access to these detailed genetic maps could help doctors in the future determine which chemotherapy drug a patient should get, based on their cancer’s genome.” This discovery already promises to improve the treatment of at least one of these groups after the researchers noticed an existing class of chemotherapy drugs, used to treat some breast cancers, may also work on patients whose pancreatic tumours have the “unstable” genomes. The team of researchers realised the significance of their discovery when they found four out of five study patients with this genetic signature responded to the DNA-damaging drugs. “Two of them had an exceptional response, which happens very, very rarely in pancreatic cancer. Their tumours went away completely,” said the co-leader of the group, Andrew Biankin, who conducted the work at the Garvan Institute of Medical Research. Dr Nicola Waddell from QIMR Berghofer (previously from IMB) said pancreatic cancer remained one of the most complex cancers to treat, with a survival rate that has not improved considerably in the last 50 years. “Our study identified four major genomic subtypes in pancreatic cancer, revealed two new driver genes not previously associated with pancreatic cancer, and reaffirmed the importance of five key genes,” said Dr, Waddell. The team at IMB plan to begin a clinical trial in the UK, selecting patients for targeted treatments based on their genomic testing. The ACRF is proud to have supported each the Australian research centres involved in this study with funding over many years.