Dr Vanessa Hayes, Garvan Institute of Medical Research
Recent discoveries within this group utilising the technology within the ACRF Unit for Molecular Genetics of Cancer:
In addition to the androgen receptor gene, six more genes have been assessed within our large Australian prostate cancer case-control study (nation-wide collaborative effort) and markers of predisposition have been identified.Both prostate cancer and male pattern balding are dependent on androgens (male hormones), thus implicating the androgen receptor gene in these male conditions.
Both prostate cancer and male pattern balding are dependent on androgens (male hormones), thus implicating the androgen receptor gene in these male conditions.Male patterned balding (in particular the circular vertex pattern of balding) has previously been loosely associated with prostate cancer risk.We found no overall association between genetic markers of this gene and prostate cancer risk (1,600 prostate cancer cases and controls), however we did observe a significant association with metastatic disease in 800 prostate cancer cases.A highly significant association with male patterned balding was observed.
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