Dr Jac Charlesworth
Research Fellow – Genetics
Research Interests:
Dr Charlesworth is interested in the analysis of a wide range of genetic and genomic data, including large-pedigree based joint linkage and association analysis, analysis of expression data and integration of expression information with other genetic data, next-generation sequence analysis as well as pathway based approached for the interrogation of GWAS and expression datasets. She has a particular interest in normal variation of brain related phenotypes and their relevance to disorders such as multiple sclerosis in collaboration with the Southwest Foundation for Biomedical Research, USA. She also works on the genetics of glaucoma in collaboration with the Oregon Health and Science University, USA and Flinders University, South Australia.
Research Projects:
- The identification of genes underlying a familial susceptibility to blood cancers
- Identification of genes underscoring susceptibility of humans to prostate cancer
- Pathway based approached to extract more information from previous GWAS datasets such as the Australian and New Zealand MS genetics consortium datasets
- Using normal variation in brain structure and function to inform the search for genes influencing multiple sclerosis susceptibility
- Applying genomic methods to investigate the influence of environmental measures, such as smoking, on gene function and disease
- Investigating the genetics of primary open angle glaucoma using an endophenotype approach in large pedigrees (OHUS collaboration, USA)
- The Genetics of brain structure and function study (GOBS; SFBR collaboration USA)
- A genome-wide association scan for glaucoma (Flinders University)
